Uterine transplantation: a new path to parenthood

For women born without a uterus or who have lost it, uterine transplantation has moved from experiment to reality, with hundreds of births worldwide.

It remains, however, a complex, demanding procedure with significant requirements.

Who is it for?

Mainly women with ‘absolute uterine-factor infertility’ — an absent uterus (for example MRKH syndrome) or its removal. It is an alternative to surrogacy or adoption.

How does the process work?

IVF comes first, to create and freeze embryos. A uterus is then transplanted from a donor, followed by a stabilisation period on immunosuppression, and then an embryo transfer.

Have healthy children been born?

Yes. Since the first birth in 2014, hundreds of healthy children have been born internationally, from both living and deceased donors.

What are the risks and limits?

It is major surgery requiring immunosuppression during pregnancy. The uterus is usually removed after one or two children. It is performed in a handful of specialised centres, within studies.

The key message

Uterine transplantation is a real but specialised option for selected women, with significant benefits and demands — and it keeps advancing.